Oklahoma Highway Patrol (OHP) said the scene of the crash, which took place on Wednesday, was located near Manning Road and Memorial Road, north-west of the city.
The small plane reportedly clipped a broadcast tower before crashing into a creek.
Trooper Matt Conway expressed his shock at the event, and said the victim was a crop duster pilot who performed the task almost daily.
He added the pilot was spraying weed killer on nearby fields before crashing into a communications tower.
He was flying and making a turn I believe, and struck the guide wire for the cell tower behind us
The pilot was one of just a few people who carried out the task in the area.
Mr Conway said: “He was flying and making a turn I believe, and struck the guide wire for the cell tower behind us.”
The OHP said the man was flying in a single fixed-wing aeroplane when he lost control.
Another pilot flew over the crash site, and recorded footage of the collapsed radio tower and smoke rising from the scene.
The OHP has not yet released the identity of the pilot.
They also refused to reveal the victim’s employer.
The site will remain closed until the Federal Aviation Administration and National Transportation Safety Board officials arrive on the scene on Thursday.
Officials are advising people to avoid Manning Road, north of Memorial Road, between Yukon and El Reno.